| Registro completo |
| Provedor de dados: |
OceanDocs
|
| País: |
Belgium
|
| Título: |
Repair of UVB-Damaged Skin by the antioxidant sulphated flavone glycoside Thalassiolin B Isolated from the marine plant Thalassia testudinum Banks ex König
|
| Autores: |
Regalado, E.L.
Rodríguez, M.
Menéndez, R.
Concepción, A.A.
Nogueiras, C.
Laguna, A.
Rodríguez, A.A.
Williams, D.E.
Lenzo-Luaces, P.
Valdés, O.
Hernandez, Y.
|
| Data: |
2011-03-11
|
| Ano: |
2009
|
| Palavras-chave: |
Chemistry
Pharmacology
Chemistry
Pharmacology
Http://aims.fao.org/aos/agrovoc/c_1522
Http://aims.fao.org/aos/agrovoc/c_5760
|
| Resumo: |
Daily topical application of the aqueous ethanolic extract of the marine sea grass, Thalassia testudinum, on mice skin exposed to UVB radiation resulted in a dose dependent recovery of the skin macroscopic alterations over a 6-day period. Maximal effect (90%) occurred at a dose of 240 μg/cm2, with no additional effects at higher doses. Bioassay-guided fractionation of the plant extract resulted in the isolation of thalassiolin B (1). Topical application of 1 (240 μg/cm2) markedly reduces skin UVB-induced damage. In addition, thalassiolin B scavenged 2,2-diphenyl-2-picrylhydrazyl radical with an EC50=100 μg/ml. These results suggest that thalassiolin B is responsible for the skin regenerating effects of the crude extract of T. testudinum
|
| Tipo: |
Journal Contribution
|
| Idioma: |
Inglês
|
| Identificador: |
Marine biotechnology, 11(1). p. 74-80
http://hdl.handle.net/1834/3865
|
| Relação: |
http://www.springerlink.com/content/x325587654j91816/
|
|
